H-Channels Affect Frequency, Power and Amplitude Fluctuations of Neuronal Network Oscillations.

ABSTRACT: Oscillations in network activity are ubiquitous in the brain and are involved in diverse cognitive functions. Oscillation characteristics, such as power, frequency, and temporal structure, depend on both network connectivity and intrinsic cellular properties, such as ion channel composition. An important class of channels, with key roles in regulating cell excitability, are h-channels. The h-current (Ih) is a slow, hyperpolarization-activated, depolarizing current that contributes to neuronal resonance and membrane potential. The impact of Ih on network oscillations, however, remains poorly understood. To elucidate the network effects of Ih, we used a computational model of a generic oscillatory neuronal network consisting of inhibitory and excitatory cells that were externally driven by e

SUBMITTER: Avella Gonzalez OJ 

PROVIDER: S-EPMC4652018 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature