Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy.

ABSTRACT: Diabetic nephropathy (DN) is a serious complication of both type 1 and type 2 diabetes mellitus. The disease is now the most common cause of end-stage kidney disease (ESKD) in developed countries, and both the incidence and prevalence of diabetes mellitus is increasing worldwide. Current treatments are directed at controlling hyperglycemia and hypertension, as well as blockade of the renin angiotensin system with angiotensin-converting enzyme inhibitors (ACEIs), and angiotensin receptor blockers. Despite these therapies, DN progresses to ESKD in many patients. As a result, much interest is focused on developing new therapies. It has been over two decades since ACEIs were shown to have beneficial effects in DN independent of their blood pressure-lowering actions. Since that time, our unders

SUBMITTER: Johnson SA 

PROVIDER: S-EPMC4652076 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature