Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma.

ABSTRACT: Biological networks display high robustness against random failures but are vulnerable to targeted attacks on central nodes. Thus, network topology analysis represents a powerful tool for investigating network susceptibility against targeted node removal. Here, we built protein interaction networks associated with chemoresistance to temozolomide, an alkylating agent used in glioma therapy, and analyzed their modular structure and robustness against intentional attack. These networks showed functional modules related to DNA repair, immunity, apoptosis, cell stress, proliferation and migration. Subsequently, network vulnerability was assessed by means of centrality-based attacks based on the removal of node fractions in descending orders of degree, betweenness, or the product of degree and b

SUBMITTER: Azevedo H 

PROVIDER: S-EPMC4652178 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature