Ontology highlight
ABSTRACT:
SUBMITTER: Kim JM
PROVIDER: S-EPMC4652225 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Kim Jin-Man JM Kim Kyunghwan K Punj Vasu V Liang Gangning G Ulmer Tobias S TS Lu Wange W An Woojin W
Scientific reports 20151119
Linker histone H1 is a protein component of chromatin and has been linked to higher-order chromatin compaction and global gene silencing. However, a growing body of evidence suggests that H1 plays a gene-specific role, regulating a relatively small number of genes. Here we show that H1.2, one of the H1 subtypes, is overexpressed in cancer cells and contributes to gene silencing. H1.2 gets recruited to distinct chromatin regions in a manner dependent on EZH2-mediated H3K27me3, and inhibits transc ...[more]