Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease.

ABSTRACT:

Unlabelled

Neurofibrillary tau pathology and amyloid β (Aβ) plaques, characteristic lesions of Alzheimer disease (AD), show different neocortical laminar distributions. Neurofibrillary-tangle tau pathology tends to be closer to the gray matter-white matter boundary, whereas Aβ is dispersed throughout the width of the cortical ribbon.

Methods

Using PET radiotracers for tau and Aβ lesions, we developed an image analysis tool to measure the distance of tracer-positive voxels from the gray matter-white matter boundary. We studied 5 AD and 5 healthy subjects with both (18)F-THK5117 (tau) and (11)C-Pittsburgh compound B (Aβ) PET.

Results

On average, tau-positive voxels were closer to the white matter than were Aβ-positive voxels. This effect was found for all AD subjects an

SUBMITTER: Li Y 

PROVIDER: S-EPMC4652320 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature