Dendritic cells and macrophages neurally hard-wired in the lymph node.

ABSTRACT: The neural hard-wired pathways in which the lymphoid organs are innervated by the nervous system is of special interest with respect to suggested afferent and sensory systems informing the central nervous system about the status of the immune system. Until today efferent also like afferent innervation seem to be unspecific, targeting many types of cells by affecting many cells at the same time. We for the first time show that antigen presenting cells (APC) are abundantly innervated in the T-cell enriched area, the subsinoidal layer and the cortical extrafollicular zone of lymph nodes in rats by a mesh of filamentous neurofilament positive structures originating from single nerve fibers and covering each single APC similar to a glass fishing float, so that we termed them "wired" APC (wAPC).

SUBMITTER: Wulfing C 

PROVIDER: S-EPMC4652329 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature