Novel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms.

ABSTRACT:

Background

Tropomyosin-related kinase A (TRKA) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. It is critical for the correct development of many types of neurons including pain-mediating sensory neurons and also controls proliferation, differentiation and survival of many neuronal and non-neuronal cells. TRKA (also known as NTRK1) gene is a target of alternative splicing which can result in several different protein isoforms. Presently, three human isoforms (TRKAI, TRKAII and TRKAIII) and two rat isoforms (TRKA L0 and TRKA L1) have been described.

Results

We show here that human TRKA gene is overlapped by two genes and spans 67 kb--almost three times the size that has been previously described. Numerous transcription initiation s

SUBMITTER: Luberg K 

PROVIDER: S-EPMC4652384 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature