Identification and annotation of conserved promoters and macrophage-expressed genes in the pig genome.

ABSTRACT:

Background

The FANTOM5 consortium used Cap Analysis of Gene Expression (CAGE) tag sequencing to produce a comprehensive atlas of promoters and enhancers within the human and mouse genomes. We reasoned that the mapping of these regulatory elements to the pig genome could provide useful annotation and evidence to support assignment of orthology.

Results

For human transcription start sites (TSS) associated with annotated human-mouse orthologs, 17% mapped to the pig genome but not to the mouse, 10% mapped only to the mouse, and 55% mapped to both pig and mouse. Around 17% did not map to either species. The mapping percentages were lower where there was not clear orthology relationship, but in every case, mapping to pig was greater than to mouse, and the degree of homology was al

SUBMITTER: Robert C 

PROVIDER: S-EPMC4652390 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature