Microarray Analysis of Human Blood During Electroconvulsive Therapy.

ABSTRACT:

Introduction

Electroconvulsive therapy (ECT) is currently regarded as a significant treatment option for intractable psychiatric disorders, such as catatonic schizophrenia or treatment-resistant depression; however, the underlying molecular mechanism for its therapeutic effect remains obscure.

Methods

Employing microarray analysis (Human Genome U133 Plus 2.0 Array; Affymetrix, United States) of cDNA derived from the peripheral blood of patients with catatonic schizophrenia (n = 5), we detected a significant change in 145 genes (0.68%) before and after modified ECT (mECT). Moreover, we performed quantitative polymerase chain reaction validation of genes that had previously been suggested to be functionally related to schizophrenia.

Results

Of 4 genes examined (AKT3, TC

SUBMITTER: Kaneko T 

PROVIDER: S-EPMC4652629 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature