Corneal graft rejection 10 years after penetrating keratoplasty in the cornea donor study.

ABSTRACT:

Purpose

The aim of this study was to assess the effect of donor and recipient factors on corneal allograft rejection and evaluate whether a rejection event was associated with graft failure.

Methods

One thousand ninety subjects undergoing penetrating keratoplasty for a moderate risk condition (principally Fuchs dystrophy or pseudophakic corneal edema) were followed for up to 12 years. Associations of baseline recipient and donor factors with the occurrence of a rejection event were assessed in univariate and multivariate proportional hazards models.

Results

Among 651 eyes with a surviving graft at 5 years, the 10-year graft failure (±99% confidence interval) rates were 12% ± 4% among eyes with no rejection events in the first 5 years, 17% ± 12% in eyes with at least 1

SUBMITTER: Dunn SP 

PROVIDER: S-EPMC4653080 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature