Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder.

ABSTRACT:

Objective

To investigate the expression of α-synuclein in colonic biopsies of patients with idiopathic REM sleep behavior disorder (iRBD) and address if α-synuclein immunostaining of tissue obtained via colonic biopsies holds promise as a diagnostic biomarker for prodromal Parkinson disease (PD).

Methods

Patients with iRBD, patients with PD, and healthy controls were prospectively recruited to undergo colonic biopsies for comparison of α-synuclein immunoreactivity patterns between the groups by using 2 different antibodies.

Results

There was no difference in colonic mucosal and submucosal immunostaining between groups using the 15G7 α-synuclein antibody, which was found in almost all participants enrolled in this study. By contrast, immunostaining for serine 129-phosp

SUBMITTER: Sprenger FS 

PROVIDER: S-EPMC4653104 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature