Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.

ABSTRACT:

Objective

To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies.

Methods

In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 with clinical dementia with Lewy bodies (DLB), 181 with multiple system atrophy (MSA), 832 with pathologically confirmed Lewy body disease (LBD), and 2,456 healthy controls.

Results

The minor allele frequencies (MAF) in clinical PD cases (0.28%) and in controls (0.2%) were not found to be significantly different (odds ratio [OR] 1.37, 95% confidence interval [CI] 0.63-2.98, p = 0.42). However, a significant association was observed with clinical DLB (MAF 0

SUBMITTER: Labbe C 

PROVIDER: S-EPMC4653108 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature