Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging.

ABSTRACT:

Objective

To understand the neuropsychological basis of dementia risk among persons in the spectrum including cognitive normality and mild cognitive impairment.

Methods

We quantitated risk of progression to dementia in elderly persons without dementia from 2 population-based studies, the Framingham Heart Study (FHS) and Mayo Clinic Study of Aging (MCSA), aged 70 to 89 years at enrollment. Baseline cognitive status was defined by performance in 4 domains derived from batteries of neuropsychological tests (that were similar but not identical for FHS and MCSA) at cut scores corresponding to SDs of ≤-0.5, -1, -1.5, and -2 from normative means. Participants were characterized as having no cognitive impairment (reference group), or single or multiple amnestic or nonamnestic profil

SUBMITTER: Knopman DS 

PROVIDER: S-EPMC4653114 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature