Ontology highlight
ABSTRACT:
SUBMITTER: Karlsson P
PROVIDER: S-EPMC4653147 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Karlsson Patricia P Christie Michael Danger MD Seymour Danelle K DK Wang Huan H Wang Xi X Hagmann Jörg J Kulcheski Franceli F Manavella Pablo Andrés PA
Proceedings of the National Academy of Sciences of the United States of America 20151028 45
The biogenesis of microRNAs (miRNAs), which regulate mRNA abundance through posttranscriptional silencing, comprises multiple well-orchestrated processing steps. We have identified the Arabidopsis thaliana K homology (KH) domain protein REGULATOR OF CBF GENE EXPRESSION 3 (RCF3) as a cofactor affecting miRNA biogenesis in specific plant tissues. MiRNA and miRNA-target levels were reduced in apex-enriched samples of rcf3 mutants, but not in other tissues. Mechanistically, RCF3 affects miRNA biogen ...[more]