LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.

ABSTRACT: The hemangioblast is a progenitor cell with the capacity to give rise to both hematopoietic and endothelial progenitors. Currently, the regulatory mechanisms underlying hemangioblast formation are being elucidated, whereas those controllers for the selection of hematopoietic or endothelial fates still remain a mystery. To answer these questions, we screened for zebrafish mutants that have defects in the hemangioblast expression of Gata1, which is never expressed in endothelial progenitors. One of the isolated mutants, it627, showed not only down-regulation of hematopoietic genes but also up-regulation of endothelial genes. We identified the gene responsible for the it627 mutant as the zebrafish homolog of Lys-specific demethylase 1 (LSD1/KDM1A). Surprisingly, the hematopoietic defects in l

SUBMITTER: Takeuchi M 

PROVIDER: S-EPMC4653156 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature