Dynamic membrane protein topological switching upon changes in phospholipid environment.

ABSTRACT: A fundamental objective in membrane biology is to understand and predict how a protein sequence folds and orients in a lipid bilayer. Establishing the principles governing membrane protein folding is central to understanding the molecular basis for membrane proteins that display multiple topologies, the intrinsic dynamic organization of membrane proteins, and membrane protein conformational disorders resulting in disease. We previously established that lactose permease of Escherichia coli displays a mixture of topological conformations and undergoes postassembly bidirectional changes in orientation within the lipid bilayer triggered by a change in membrane phosphatidylethanolamine content, both in vivo and in vitro. However, the physiological implications and mechanism of dynamic structura

SUBMITTER: Vitrac H 

PROVIDER: S-EPMC4653158 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature