YKL-40 and genetic status of CHI3L1 in a large group of asthmatics.

ABSTRACT:

Background

Studies have shown a relationship between asthma, serum YKL-40, and the single nucleotide polymorphism (SNP) (-131 C/G, rs4950928) in the CHI3L1 gene that codes for YKL-40. However, the findings differ. We studied the relationship between clinical asthma phenotypes, serum YKL-40, and SNP (-131 C/G, rs4950928).

Methods

In this study, 1,137 patients with asthma, 415 with rhinitis only, and 275 non-asthmatic controls were included. Assessment included a clinical interview concerning the diagnosis of asthma, severity of asthma, and asthma treatment as well as clinical tests to assess asthma and rhinitis. Serum YKL-40 was measured, and genotyping for the SNP (-131 C/G) was conducted.

Results

No significant difference in the serum concentration of YKL-40 was foun

SUBMITTER: Hansen JW 

PROVIDER: S-EPMC4653313 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature