Genetic vasopressin 1b receptor variance in overweight and diabetes mellitus.

ABSTRACT: OBJECTIVE:Recently, imbalance in the vasopressin (AVP) system, measured as elevated levels of copeptin (the C-terminal part of the AVP pro-hormone) in plasma, was linked to the development of abdominal obesity and diabetes mellitus (DM). Here, we aim to investigate if the genetic variation of the human AVP receptor 1b gene (AVPR1B) is associated with measures of obesity and DM. DESIGN:Malmö Diet and Cancer study (MDC) is a population-based prospective cohort examined 1991-1996. METHODS:Four tag single nucleotide polymorphisms (SNPs: rs35810727, rs28373064, rs35439639, rs35608965) of AVPR1B were genotyped in the cardiovascular cohort (n=6103) of MDC (MDC-CC) and associated with measures of obesity and DM. Significant SNPs were replicated in another 24 344 MDC individuals (MDC replication co

SUBMITTER: Enhorning S 

PROVIDER: S-EPMC4653349 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature