Variation in CACNA1C is Associated with Amygdala Structure and Function in Adolescents.

ABSTRACT:

Objective

Genome-wide association studies have identified allelic variation in CACNA1C as a risk factor for multiple psychiatric disorders associated with limbic system dysfunction, including bipolar disorder, schizophrenia, and depression. The CACNA1C gene codes for a subunit of L-type voltage-gated calcium channels, which modulate amygdala function. Although CACNA1C genotype appears to be associated with amygdala morphology and function in adults with and without psychopathology, whether genetic variation influences amygdala structure and function earlier in development has not been examined.

Methods

In this first investigation of the neural correlates of CACNA1C in young individuals, we examined associations between two single nucleotide polymorphisms in CACNA1C (rs100673

SUBMITTER: Sumner JA 

PROVIDER: S-EPMC4653820 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature