Endothelin-1 gene polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus.

ABSTRACT:

Background and aims

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease worldwide and is associated with increased cardiovascular mortality. The endothelin system has been implicated in the pathogenesis of arterial hypertension and renal dysfunction. In the present study, the association of DKD with polymorphisms in ET-1 (EDN1) and ETRA (EDNRA) genes was analyzed in patients with type 2 diabetes mellitus (T2DM).

Methods

A case-control study was conducted in 548 white T2DM patients. Patients with proteinuria or on dialysis were considered cases and patients with normoalbuminuria were considered controls. Two polymorphisms in the EDN1 gene (rs1800541 and rs57072783) and five in EDNRA gene (rs6842241; rs4835083; rs4639051; rs5333 and rs5343) were genot

SUBMITTER: Zanatta CM 

PROVIDER: S-EPMC4653842 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature