Transcriptomic characterization of the dorsal lobes after hepatectomy of the ventral lobe in zebrafish.

ABSTRACT:

Background

The liver possesses an ability of compensatory growth after removing three of five lobes in mammals or one of three lobes in zebrafish. The reenter of hepatocytes into the cell cycle is one of the hallmarks for the initiation of liver compensatory growth, but cellular and molecular mechanisms underlying the activation of hepatocytes remain largely unknown.

Results

To better understand the process, transcriptional profiles of the remaining liver dorsal lobes in female zebrafish were generated with RNA-seq. About 44 million raw reads were obtained from three sequencing libraries and 71 % of raw reads were mapped to the reference genome of zebrafish. A total number of 5652 genes were differentially expressed in at least one of two time points during the compensatory

SUBMITTER: Feng G 

PROVIDER: S-EPMC4653908 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature