Neutrophil transcriptional profile changes during transit from bone marrow to sites of inflammation.

ABSTRACT: It has recently been established that neutrophils, the most abundant leukocytes, are capable of changes in gene expression during inflammatory responses. However, changes in the transcriptome as the neutrophil leaves the bone marrow have yet to be described. We hypothesized that neutrophils are transcriptionally active cells that alter their gene expression profiles as they migrate into the vasculature and then into inflamed tissues. Our goal was to provide an overview of how the neutrophil's transcriptome changes as they migrate through different compartments using microarray and bio-informatic approaches. Our study demonstrates that neutrophils are highly plastic cells where normal environmental cues result in a site-specific neutrophil transcriptome. We demonstrate that neutrophil genes

SUBMITTER: Lakschevitz FS 

PROVIDER: S-EPMC4654371 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature