Finding New Order in Biological Functions from the Network Structure of Gene Annotations.

ABSTRACT: The Gene Ontology (GO) provides biologists with a controlled terminology that describes how genes are associated with functions and how functional terms are related to one another. These term-term relationships encode how scientists conceive the organization of biological functions, and they take the form of a directed acyclic graph (DAG). Here, we propose that the network structure of gene-term annotations made using GO can be employed to establish an alternative approach for grouping functional terms that captures intrinsic functional relationships that are not evident in the hierarchical structure established in the GO DAG. Instead of relying on an externally defined organization for biological functions, our approach connects biological functions together if they are performed by the s

SUBMITTER: Glass K 

PROVIDER: S-EPMC4654495 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature