Translational utility of experimental autoimmune encephalomyelitis: recent developments.

ABSTRACT: Multiple sclerosis (MS) is a complex autoimmune condition with firmly established genetic and environmental components. Genome-wide association studies (GWAS) have revealed a large number of genetic polymorphisms in the vicinity of, and within, genes that associate to disease. However, the significance of these single-nucleotide polymorphisms in disease and possible mechanisms of action remain, with a few exceptions, to be established. While the animal model for MS, experimental autoimmune encephalomyelitis (EAE), has been instrumental in understanding immunity in general and mechanisms of MS disease in particular, much of the translational information gathered from the model in terms of treatment development (glatiramer acetate and natalizumab) has been extensively summarized. In this rev

SUBMITTER: Guerreiro-Cacais AO 

PROVIDER: S-EPMC4654535 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature