Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice.

ABSTRACT:

Introduction

Nicotine withdrawal is characterized by both affective and cognitive symptoms. Identifying genetic polymorphisms that could affect the symptoms associated with nicotine withdrawal are important in predicting withdrawal sensitivity and identifying personalized cessation therapies. In the current study we used a mouse model of a non-synonymous single nucleotide polymorphism in the translated region of the brain-derived neurotrophic factor (BDNF) gene that substitutes a valine (Val) for a methionine (Met) amino acid (Val66Met) to examine the relationship between the Val66Met single nucleotide polymorphism and nicotine dependence.

Methods

This study measured proBDNF and the BDNF prodomain levels following nicotine and nicotine withdrawal and examined a mouse model o

SUBMITTER: Lee BG 

PROVIDER: S-EPMC4654761 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature