Patterns of gene expression and DNA methylation in human fetal and adult liver.

ABSTRACT:

Background

DNA methylation is an important epigenetic control mechanism that has been shown to be associated with gene silencing through the course of development, maturation and aging. However, only limited data are available regarding the relationship between methylation and gene expression in human development.

Results

We analyzed the methylome and transcriptome of three human fetal liver samples (gestational age 20-22 weeks) and three adult human liver samples. Genes whose expression differed between fetal and adult numbered 7,673. Adult overexpression was associated with metabolic pathways and, in particular, cytochrome P450 enzymes while fetal overexpression reflected enrichment for DNA replication and repair. Analysis for DNA methylation using the Illumina Infinium 45

SUBMITTER: Huse SM 

PROVIDER: S-EPMC4654795 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature