Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its sister Leptomonas.

ABSTRACT:

Background

Leptomonas is monogenetic kinetoplastid parasite of insects and is primitive in comparison to Leishmania. Comparative studies of these two kinetoplastid may share light on the evolutionary transition to dixenous parasitism in Leishmania. In order to adapt and survive within two hosts, Leishmania species must have acquired virulence factors in addition to mechanisms that mediate susceptibility/resistance to infection in the pathology associated with disease. Rab proteins are key mediators of vesicle transport and contribute greatly to the evolution of complexity of membrane transport system. In this study we used our whole genome sequence data of these two divergent kinetoplastids to analyze the orthologues/paralogues of Rab proteins.

Results

During change of lifes

SUBMITTER: Chauhan IS 

PROVIDER: S-EPMC4654808 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature