Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis.

ABSTRACT:

Background

Trachipleistophora hominis was isolated from an HIV/AIDS patient and is a member of a highly successful group of obligate intracellular parasites.

Methods

Here we have investigated the evolution of the parasite and the interplay between host and parasite gene expression using transcriptomics of T. hominis-infected rabbit kidney cells.

Results

T. hominis has about 30% more genes than small-genome microsporidians. Highly expressed genes include those involved in growth, replication, defence against oxidative stress, and a large fraction of uncharacterised genes. Chaperones are also highly expressed and may buffer the deleterious effects of the large number of non-synonymous mutations observed in essential T. hominis genes. Host expression suggests a general c

SUBMITTER: Watson AK 

PROVIDER: S-EPMC4654818 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature