Transcriptional response to interferon beta-1a treatment in patients with secondary progressive multiple sclerosis.

ABSTRACT:

Background

Interferon (IFN) beta-1a is an approved treatment for relapsing remitting multiple sclerosis (RRMS) and has been examined for use in secondary progressive multiple sclerosis (SPMS). However, no information regarding blood transcriptional changes induced by IFN treatment in SPMS patients is available. Our aim was to identify a subgroup of SPMS patients presenting a gene expression signature similar to that of RRMS patients who are clinical responders to IFN treatment.

Methods

SPMS patients (n = 50, 20 IFN treated and 30 untreated) were classified using unsupervised hierarchical clustering according to IFN inducible gene expression profile identified in RRMS clinical responders to treatment. IFN inducible gene expression profile was determined by finding differentia

SUBMITTER: Gurevich M 

PROVIDER: S-EPMC4654830 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature