A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels.

ABSTRACT:

Background

A deeper understanding of differences and similarities in transcriptional regulation between species can uncover important information about gene functions and the role of genes in disease. Deciphering such patterns between mice and humans is especially important since mice play an essential role in biomedical research.

Results

Here, in order to characterize evolutionary changes between humans and mice, we compared gene co-expression maps to evaluate the conservation of co-expression. We show that the conservation of co-expression connectivity of homologous genes is negatively correlated with molecular evolution rates, as expected. Then we investigated evolutionary aspects of gene sets related to functions, tissues, pathways and diseases. Genes expressed in the te

SUBMITTER: Monaco G 

PROVIDER: S-EPMC4654840 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature