Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus.

ABSTRACT: The emergence of an infectious viral disease caused by the Chinese giant salamander iridovirus (GSIV) has led to substantial economic losses. However, no more molecular information is available for the understanding of the mechanisms associated with virus-host interaction. In this study, de novo sequencing was used to obtain abundant high-quality ESTs and investigate differentially-expressed genes in the spleen of Chinese giant salamanders that were either infected or mock infected with GSIV. Comparative expression analysis indicated that 293 genes were down-regulated and 220 genes were up-regulated. Further enrichment analysis showed that the most enriched pathway is "complement and coagulation cascades", and significantly enriched diseases include "inherited thrombophilia", "immune syste

SUBMITTER: Fan Y 

PROVIDER: S-EPMC4654921 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature