Gold nanoparticles as multimodality imaging agents for brain gliomas.

ABSTRACT:

Background

Nanoparticles can be used for targeted drug delivery, in particular for brain cancer therapy. However, this requires a detailed analysis of nanoparticles from the associated microvasculature to the tumor, not easy because of the required high spatial resolution. The objective of this study is to demonstrate an experimental solution of this problem, based in vivo and post-mortem whole organ imaging plus nanoscale 3-dimensional (3D) X-ray microscopy.

Results

The use of gold nanoparticles (AuNPs) as contrast agents paved the way to a detailed high-resolution three dimensional (3D) X-ray and fluorescence imaging analysis of the relation between xenografted glioma cells and the tumor-induced angiogenic microvasculature. The images of the angiogenic microvessels reveale

SUBMITTER: Lai SF 

PROVIDER: S-EPMC4654925 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature