Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank.

ABSTRACT: Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder linked to repetitive traumatic brain injury (TBI) and characterized by deposition of hyperphosphorylated tau at the depths of sulci. We sought to determine the presence of CTE pathology in a brain bank for neurodegenerative disorders for individuals with and without a history of contact sports participation. Available medical records of 1721 men were reviewed for evidence of past history of injury or participation in contact sports. Subsequently, cerebral cortical samples were processed for tau immunohistochemistry in cases with a documented history of sports exposure as well as age- and disease-matched men and women without such exposure. For cases with available frozen tissue, genetic analysis was performe

SUBMITTER: Bieniek KF 

PROVIDER: S-EPMC4655127 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature