Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis.

ABSTRACT:

Aim

To investigate the relationship of iron indices with diabetes mellitus (DM) in those without hemochromatosis.

Methods

This cross-sectional study examined data collected during the Third National Health and Nutrition Examination Survey (NHANES III). Only those who fasted properly and were not anemic with transferrin saturation < 45% were included (n = 6849). Insulin sensitivity and beta cell function were calculated from fasting glucose and insulin concentrations. Indices of iron metabolism were examined in the presence or absence of DM. We examined the relationship of insulin sensitivity and beta cell function with serum ferritin concentration. The influence of C-reactive protein and liver enzymes was also investigated.

Results

Serum ferritin concentration was sig

SUBMITTER: Huang J 

PROVIDER: S-EPMC4655253 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature