Genomic epidemiology of age-associated meningococcal lineages in national surveillance: an observational cohort study.

ABSTRACT:

Background

Invasive meningococcal disease (IMD) is a worldwide health issue that is potentially preventable with vaccination. In view of its sporadic nature and the high diversity of Neisseria meningitidis, epidemiological surveillance incorporating detailed isolate characterisation is crucial for effective control and understanding the evolving epidemiology of IMD. The Meningitis Research Foundation Meningococcus Genome Library (MRF-MGL) exploits whole-genome sequencing (WGS) for this purpose and presents data on a comprehensive and coherent IMD isolate collection from England and Wales via the internet. We assessed the contribution of these data to investigating IMD epidemiology.

Methods

WGS data were obtained for all 899 IMD isolates available for England and Wales in epi

SUBMITTER: Hill DM 

PROVIDER: S-EPMC4655307 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature