Stochastic electrotransport selectively enhances the transport of highly electromobile molecules.

ABSTRACT: Nondestructive chemical processing of porous samples such as fixed biological tissues typically relies on molecular diffusion. Diffusion into a porous structure is a slow process that significantly delays completion of chemical processing. Here, we present a novel electrokinetic method termed stochastic electrotransport for rapid nondestructive processing of porous samples. This method uses a rotational electric field to selectively disperse highly electromobile molecules throughout a porous sample without displacing the low-electromobility molecules that constitute the sample. Using computational models, we show that stochastic electrotransport can rapidly disperse electromobile molecules in a porous medium. We apply this method to completely clear mouse organs within 1-3 days and to stai

SUBMITTER: Kim SY 

PROVIDER: S-EPMC4655572 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature