Independent association between serum sclerostin levels and carotid artery atherosclerosis in prevalent haemodialysis patients.

ABSTRACT:

Background

Sclerostin is a soluble inhibitor of the Wnt signalling pathway and has been shown to be associated with decreased bone turnover and vascular and/or valvular calcification in patients with chronic kidney disease. Common carotid artery intima-media thickness (CIMT) assessment and common carotid artery (CCA) plaque identification with ultrasound imaging are well-recognized tools for the identification and monitoring of atherosclerosis. The aim of the present study was to investigate whether the circulating levels of sclerostin might be associated with carotid artery atherosclerosis in prevalent haemodialysis patients.

Methods

In this cross-sectional study, serum sclerostin concentrations were measured using a commercially available enzyme-linked immunosorbent assay

SUBMITTER: Kirkpantur A 

PROVIDER: S-EPMC4655787 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature