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Establishment and Dysfunction of the Blood-Brain Barrier.

ABSTRACT: Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC4655822 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Establishment and Dysfunction of the Blood-Brain Barrier.

Zhao Zhen Z   Nelson Amy R AR   Betsholtz Christer C   Zlokovic Berislav V BV  

Cell 20151101 5

Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurologic  ...[more]

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