Characterisation and imaging of cortical impedance changes during interictal and ictal activity in the anaesthetised rat.

ABSTRACT: Epilepsy affects approximately 50 million people worldwide, and 20-30% of these cases are refractory to antiepileptic drugs. Many patients with intractable epilepsy can benefit from surgical resection of the tissue generating the seizures; however, difficulty in precisely localising seizure foci has limited the number of patients undergoing surgery as well as potentially lowered its effectiveness. Here we demonstrate a novel imaging method for monitoring rapid changes in cerebral tissue impedance occurring during interictal and ictal activity, and show that it can reveal the propagation of pathological activity in the cortex. Cortical impedance was recorded simultaneously to ECoG using a 30-contact electrode mat placed on the exposed cortex of anaesthetised rats, in which interictal spikes

SUBMITTER: Vongerichten AN 

PROVIDER: S-EPMC4655942 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature