Contributions of Ca2+-Independent Thin Filament Activation to Cardiac Muscle Function.

ABSTRACT: Although Ca2+ is the principal regulator of contraction in striated muscle, in vitro evidence suggests that some actin-myosin interaction is still possible even in its absence. Whether this Ca2+-independent activation (CIA) occurs under physiological conditions remains unclear, as does its potential impact on the function of intact cardiac muscle. The purpose of this study was to investigate CIA using computational analysis. We added a structurally motivated representation of this phenomenon to an existing myofilament model, which allowed predictions of CIA-dependent muscle behavior. We found that a certain amount of CIA was essential for the model to reproduce reported effects of nonfunctional troponin C on myofilament force generation. Consequently, those data enabled estimation of ΔGCIA

SUBMITTER: Aboelkassem Y 

PROVIDER: S-EPMC4656859 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature