Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo.

ABSTRACT: Inflammation is a biological response associated with symptoms of various diseases, and its study is important in gaining an understanding of the pathological conditions of such diseases and in making strategic plans for promoting healing. It is therefore essential to develop technologies for the detection of inflammatory conditions. Interleukin-1β (IL-1β) is a proinflammatory cytokine produced and secreted mainly by monocytes and macrophages in response to inflammatory stimulation. The activation of IL-1β is regulated through transcriptional induction by the promoter and post-translational processing by the inflammasome. Here we have developed a reporter gene to monitor the activation status of IL-1β by using a dual regulation system and, by using the reporter gene, we have established a

SUBMITTER: Iwawaki T 

PROVIDER: S-EPMC4657042 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature