The autophagic response to polystyrene nanoparticles is mediated by transcription factor EB and depends on surface charge.

ABSTRACT:

Background

A number of engineered nanoparticles induce autophagy, the main catabolic pathway that regulates bulk degradation of cytoplasmic material by the lysosomes. Depending on the specific physico-chemical properties of the nanomaterial, however, nanoparticle-induced autophagy may have different effects on cell physiology, ranging from enhanced autophagic degradation to blockage of autophagic flux. To investigate the molecular mechanisms underlying the impact of nanoparticle charge on the nature of the autophagic response, we tested polystyrene nanoparticles (50 nm) with neutral, anionic, and cationic surface charges.

Results

We found all polystyrene nanoparticles investigated in this study to activate autophagy. We showed that internalization of polystyrene nanoparticle

SUBMITTER: Song W 

PROVIDER: S-EPMC4657241 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature