Genetic associations and shared environmental effects on the skin microbiome of Korean twins.

ABSTRACT:

Background

The skin is the outermost layer of the human body and one of the key sites for host-microbe interactions. Both environmental and host genetic factors influence microbial communities in distinct anatomical niches, but little is known about their interplay in shaping the skin microbiome. Here, we investigate the heritable components of the skin microbiome and their association with host genetic factors.

Results

Based on our analysis of the microbiota from 45 individuals including monozygotic and dizygotic twins aged 26-55 years and their mothers, we found that skin microbial diversity was significantly influenced by age and skin pigmentation. Heritability analysis revealed genetic and shared environmental impacts on the skin microbiome. Furthermore, we observed a st

SUBMITTER: Si J 

PROVIDER: S-EPMC4657342 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature