Pharmacology and Clinical Drug Candidates in Redox Medicine.

ABSTRACT:

Significance

Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant molecules, has been unsuccessful.

Recent advances

An alternative emerging approach is to target the enzymatic sources of disease-relevant oxidative stress. Several such enzymes and isoforms have been identified and linked to different pathologies. For some targets, the respective pharmacology is quite advanced, that is, up to late-stage clinical development or even on the market; for others, drugs are already in clinical use, although not for indications based on oxidative stress, and repurposing seems to be a viable option.

Cr

SUBMITTER: Dao VT 

PROVIDER: S-EPMC4657508 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature