Clustering of Toxoplasma gondii Infections Within Families of Congenitally Infected Infants.

ABSTRACT:

Background

Family clusters and epidemics of toxoplasmosis in North, Central, and South America led us to determine whether fathers of congenitally infected infants in the National Collaborative Chicago-Based Congenital Toxoplasmosis Study (NCCCTS) have a high incidence of Toxoplasma gondii infection.

Methods

We analyzed serum samples collected from NCCCTS families between 1981 and 2013. Paternal serum samples were tested for T. gondii antibodies with immunoglobulin (Ig) G dye test and IgM enzyme-linked immunosorbent assay. Additional testing of paternal serum samples was performed with differential-agglutination and IgG avidity tests when T. gondii IgG and IgM results were positive and serum samples were collected by the 1-year visit of the congenitally infected child. Preva

SUBMITTER: Contopoulos-Ioannidis D 

PROVIDER: S-EPMC4657536 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature