Factors Associated With Complications of Clostridium difficile Infection in a Multicenter Prospective Cohort.

ABSTRACT:

Background

Clostridium difficile infection (CDI) is the most common cause of nosocomial infectious diarrhea and may result in severe complications including death. We conducted a prospective study to identify risk factors for complications of CDI (cCDI).

Methods

Adult inpatients with confirmed CDI in 10 Canadian hospitals were enrolled and followed for 90 days. Potential risk factors were measured within 24 hours of diagnosis. Isolates were typed by polymerase chain reaction ribotyping. cCDI was defined as 1 or more of the following: colonic perforation, toxic megacolon, colectomy, admission to an intensive care unit for cCDI, or if CDI contributed to death within 30 days of enrollment. Risk factors for cCDI were investigated by logistic regression.

Results

A total of

SUBMITTER: Abou Chakra CN 

PROVIDER: S-EPMC4657538 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature