Cognitive Effects of Soy Isoflavones in Patients with Alzheimer's Disease.

ABSTRACT:

Background

In a previous trial, treatment with soy isoflavones was associated with improved nonverbal memory, construction abilities, verbal fluency, and speeded dexterity compared to treatment with placebo in cognitively healthy older adults.

Objective

The current trial aimed to examine the potential cognitive benefits of soy isoflavones in patients with Alzheimer's disease.

Methods

Sixty-five men and women over the age of 60 were treated with 100 mg/day soy isoflavones, or matching placebo capsules for six months. APOE genotype was determined for all participants. Cognitive outcomes and plasma isoflavone levels were measured at baseline, and at two additional time points: three and six months after baseline.

Results

Of the sixty-five participants enrolled, th

SUBMITTER: Gleason CE 

PROVIDER: S-EPMC4657545 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature