A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.

ABSTRACT: A terbium-based complex that displays a water exchange CEST resonance well outside the normal magnetization transfer (MT) frequency range of tissues provides a direct readout of pH values by MRI. Deprotonation of the phenolic proton in this complex results in a frequency shift of 56 ppm in a bound water molecule exchange peak between pH 5 and 8. This allows direct imaging of pH without prior knowledge of the agent concentration and with essentially no interference from the tissue MT signal.

SUBMITTER: Wang X 

PROVIDER: S-EPMC4657548 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature