Ontology highlight
ABSTRACT:
SUBMITTER: Hu R
PROVIDER: S-EPMC4657560 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Immunity 20141001 4
Chronic inflammation is a contributing factor to most life-shortening human diseases. However, the molecular and cellular mechanisms that sustain chronic inflammatory responses remain poorly understood, making it difficult to treat this deleterious condition. Using a mouse model of age-dependent inflammation that results from a deficiency in miR-146a, we demonstrate that miR-155 contributed to the progressive inflammatory disease that emerged as Mir146a(-/-) mice grew older. Upon analyzing lymph ...[more]