Comparison of Basal-Bolus and Premixed Insulin Regimens in Hospitalized Patients With Type 2 Diabetes.

ABSTRACT:

Objective

Premixed insulin is a commonly prescribed formulation for the outpatient management of patients with type 2 diabetes. The safety and efficacy of premixed insulin formulations in the hospital setting is not known.

Research design and methods

In a prospective, open-label trial, we randomized general medicine and surgery patients to receive a basal-bolus regimen with glargine once daily and glulisine before meals (n = 33) or premixed human insulin (30% regular insulin and 70% NPH insulin) twice daily (n = 39). Major outcomes included differences in daily blood glucose (BG) levels and frequency of hypoglycemic events (<70 mg/dL) between treatment groups.

Results

At the first prespecified interim analysis, the study was stopped early because of an increased frequ

SUBMITTER: Bellido V 

PROVIDER: S-EPMC4657612 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature